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SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Significant relevance to folate's effects
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Read More
8
Pediatric blood clot management insights
CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE.
Research indicates folate's role
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
8
Folate's role in blood health
Cystoid Macular Edema Associated With Venous Stasis in a Patient With Previously Undiagnosed Hyperhomocysteinemia.
Explores hyperhomocysteinemia treatment
We observed a 74-year-old female patient who sought help for unilateral vision reduction attributed to cystoid macular edema and retinal venous stasis. During our examination, we noted her visual acuity was reduced in the affected left eye. Further investigation through imaging techniques confirmed her diagnosis and revealed systemic issues related to elevated homocysteine levels.
The relationship between homocysteine and vascular complications made us consider hyperhomocysteinemia as a significant risk factor for her condition. We were particularly interested in how addressing her elevated homocysteine with folate—commonly known for its role in blood health—could impact her treatment.
The patient was treated with anti-vascular endothelial growth factor (VEGF) injections and prescribed oral folic acid for life to manage her condition. We were pleased to see her vision improve significantly and maintain stability for an extended period. However, when cystoid macular edema returned, she received additional intravitreal injections, indicating ongoing vigilance was necessary.
Ultimately, our findings suggest that while folate may contribute positively to managing blood clot risks, particularly in the context of hyperhomocysteinemia, its effects can be complicated by the combined treatment of anti-VEGF injections, highlighting the complexity of such cases.
The relationship between homocysteine and vascular complications made us consider hyperhomocysteinemia as a significant risk factor for her condition. We were particularly interested in how addressing her elevated homocysteine with folate—commonly known for its role in blood health—could impact her treatment.
The patient was treated with anti-vascular endothelial growth factor (VEGF) injections and prescribed oral folic acid for life to manage her condition. We were pleased to see her vision improve significantly and maintain stability for an extended period. However, when cystoid macular edema returned, she received additional intravitreal injections, indicating ongoing vigilance was necessary.
Ultimately, our findings suggest that while folate may contribute positively to managing blood clot risks, particularly in the context of hyperhomocysteinemia, its effects can be complicated by the combined treatment of anti-VEGF injections, highlighting the complexity of such cases.
Read More
Most Useful Reviews
9.5
Health improvement noted
Many are unaware of the dangers of high blood homocysteine levels, as I was. Chronic work stress caused mine to rise, putting me at risk for blood clots. To mitigate this, I needed substances like folic acid that convert harmful homocysteine into beneficial compounds. I've been using an active form of folate from a reputable brand consistently, and my levels normalised, leading to a significant improvement in my health. I strongly recommend monitoring these levels and taking action as necessary.
Read More
4.5
Controversial folic effectiveness
I take folic acid daily, as advised by my doctor, due to issues with blood clots and miscarriage. Despite trying various forms, the conclusion remains: folic acid is well-absorbed. The idea that costly folate supplements are superior is misleading. My experiences with testing confirm that standard folic acid, available from pharmacies, is effective for my condition. Overall, I believe there is no need to spend more on expensive alternatives.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
9
Folate's role in thrombosis treatment
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Moderately relevant case findings
We observed a fascinating case involving a 14-year-old girl who experienced severe headaches and nausea, leading to the discovery of cerebral venous thrombosis (CVT) and significantly elevated plasma homocysteine levels. Through comprehensive genetic testing, we identified a rare genetic change called loss of heterozygosity (LOH) affecting the methylenetetrahydrofolate reductase (MTHFR) gene, which plays a crucial role in processing folate in the body.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
Read More
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Significant relevance to folate's effects
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Read More
8
Pediatric blood clot management insights
CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE.
Research indicates folate's role
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
8
Folate's role in blood health
Cystoid Macular Edema Associated With Venous Stasis in a Patient With Previously Undiagnosed Hyperhomocysteinemia.
Explores hyperhomocysteinemia treatment
We observed a 74-year-old female patient who sought help for unilateral vision reduction attributed to cystoid macular edema and retinal venous stasis. During our examination, we noted her visual acuity was reduced in the affected left eye. Further investigation through imaging techniques confirmed her diagnosis and revealed systemic issues related to elevated homocysteine levels.
The relationship between homocysteine and vascular complications made us consider hyperhomocysteinemia as a significant risk factor for her condition. We were particularly interested in how addressing her elevated homocysteine with folate—commonly known for its role in blood health—could impact her treatment.
The patient was treated with anti-vascular endothelial growth factor (VEGF) injections and prescribed oral folic acid for life to manage her condition. We were pleased to see her vision improve significantly and maintain stability for an extended period. However, when cystoid macular edema returned, she received additional intravitreal injections, indicating ongoing vigilance was necessary.
Ultimately, our findings suggest that while folate may contribute positively to managing blood clot risks, particularly in the context of hyperhomocysteinemia, its effects can be complicated by the combined treatment of anti-VEGF injections, highlighting the complexity of such cases.
The relationship between homocysteine and vascular complications made us consider hyperhomocysteinemia as a significant risk factor for her condition. We were particularly interested in how addressing her elevated homocysteine with folate—commonly known for its role in blood health—could impact her treatment.
The patient was treated with anti-vascular endothelial growth factor (VEGF) injections and prescribed oral folic acid for life to manage her condition. We were pleased to see her vision improve significantly and maintain stability for an extended period. However, when cystoid macular edema returned, she received additional intravitreal injections, indicating ongoing vigilance was necessary.
Ultimately, our findings suggest that while folate may contribute positively to managing blood clot risks, particularly in the context of hyperhomocysteinemia, its effects can be complicated by the combined treatment of anti-VEGF injections, highlighting the complexity of such cases.
Read More
7
Folate's role in blood clotting
The association of serum folate and homocysteine on venous thromboembolism in patients with colorectal cancer: a cross-sectional study.
Influential study on patient care
We examined the effects of serum folate and homocysteine on the occurrence of blood clots in patients with colorectal cancer. The study involved analyzing medical records of these patients, focusing on their serum folate and homocysteine levels, among other factors.
Our findings indicate that lower levels of folate were associated with a higher incidence of venous thromboembolism, a serious complication often seen in this patient group. Importantly, we observed that folate influences blood clot formation not directly, but rather through its relationship with homocysteine levels. This suggests that boosting folate could be a worthwhile strategy to manage homocysteine, potentially reducing the risk of blood clots.
Therefore, enhancing nutritional supplementation for these patients to maintain optimal serum folate and homocysteine levels could help mitigate the risk of developing venous thromboembolism. Overall, this research sheds light on the significant role that folate plays in blood clot dynamics among colorectal cancer patients.
Our findings indicate that lower levels of folate were associated with a higher incidence of venous thromboembolism, a serious complication often seen in this patient group. Importantly, we observed that folate influences blood clot formation not directly, but rather through its relationship with homocysteine levels. This suggests that boosting folate could be a worthwhile strategy to manage homocysteine, potentially reducing the risk of blood clots.
Therefore, enhancing nutritional supplementation for these patients to maintain optimal serum folate and homocysteine levels could help mitigate the risk of developing venous thromboembolism. Overall, this research sheds light on the significant role that folate plays in blood clot dynamics among colorectal cancer patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.1
9.5
Health improvement noted
Many are unaware of the dangers of high blood homocysteine levels, as I was. Chronic work stress caused mine to rise, putting me at risk for blood clots. To mitigate this, I needed substances like folic acid that convert harmful homocysteine into beneficial compounds. I've been using an active form of folate from a reputable brand consistently, and my levels normalised, leading to a significant improvement in my health. I strongly recommend monitoring these levels and taking action as necessary.
Read More
4.5
Controversial folic effectiveness
I take folic acid daily, as advised by my doctor, due to issues with blood clots and miscarriage. Despite trying various forms, the conclusion remains: folic acid is well-absorbed. The idea that costly folate supplements are superior is misleading. My experiences with testing confirm that standard folic acid, available from pharmacies, is effective for my condition. Overall, I believe there is no need to spend more on expensive alternatives.
Read More
